(+)-Bicuculline

(+)-Bicuculline is a bicyclic diterpene alkaloid known for its role as a potent antagonist of GABA-A receptors in the central nervous system. Derived from plants like Dicentra cucullaria and Adlumia fungosa, it competitively blocks the binding of γ-aminobutyric acid (GABA) to its receptors, thereby inhibiting the inhibitory actions mediated by GABA.

In neuroscience research, (+)-Bicuculline serves as a valuable pharmacological tool to study GABA-A receptor function. By inducing excitatory effects through receptor blockade, it enhances neuronal activity and is instrumental in investigating conditions such as epilepsy, synaptic plasticity, and neurodevelopmental disorders where GABAergic signaling is disrupted.

The compound’s pharmacological applications extend to experimental studies on drug addiction, anxiety disorders, and pain management, elucidating neurotransmitter interactions and potential therapeutic interventions targeting GABAergic dysfunction.

As a specialized research chemical, (+)-Bicuculline is sourced from suppliers catering to scientific and pharmaceutical research. Researchers procure (+)-Bicuculline in various forms to ensure purity and reliability for experimental use in laboratories worldwide.

Researchers interested in Buy (+)-Bicuculline online USA can find reputable suppliers offering this essential pharmacological tool. Ensuring cheap (+)-Bicuculline for sale is essential for facilitating neuroscience research and experimental studies across different applications.

In summary, (+)-Bicuculline plays a pivotal role in neuroscience and pharmacology as a selective GABA-A receptor antagonist. Its ability to modulate neuronal excitability and investigate GABAergic mechanisms underscores its importance in advancing our understanding of brain function and exploring potential treatments for neurological disorders.